Research suggests the cannabinoids in topical CBD creams may be absorbed more efficiently by the body through the skin, rather than passing through digestion, as is the case with orally ingested CBD products.
Although research in the U.S. is ongoing, preliminary studies show that topical CBD cream may be beneficial when it comes to treating chronic pain conditions, such as arthritis. However, additional well-designed human clinical trials are needed, as much of the existing research is based on animal studies or anecdotal results.
One small, placebo-controlled 2020 study in Current Pharmaceutical Biotechnology examined the use of topical CBD in 29 participants with peripheral neuropathy, a chronic pain condition caused by nerve damage. The results showed that the 15 participants using topical CBD oil experienced significantly less pain compared to the 14 participants using the placebo after four weeks.
Another 2018 study with over 300 participants with knee pain from osteoarthritis found a transdermal synthetic CBD gel significantly improved patients’ worst pain score and physical function averages. These patients were treated with 350 milligrams of CBD gel per day for 12 weeks.
Additionally, some research suggests that the anti-inflammatory properties of CBD cream may help to improve certain skin conditions such as acne and eczema.
Potential Side Effects of CBD Creams and Topicals
CBD itself is safe and well tolerated, and it has no risks of abuse or dependence, according to the World Health Organization.
“Additionally, using CBD topically reduces the likelihood of experiencing side effects typically associated with CBD use, such as drowsiness, fatigue and diarrhea,” says Dr. Milanes.
Milanes and Fuentes warn that while CBD itself might be safe, there is a chance you might be allergic or sensitive to another ingredient in a CBD topical, which could cause adverse effects. To avoid unpleasant reactions, they suggest reading ingredient lists carefully.
Phan also recommends talking to your doctor before using CBD if you’re on any medications— especially blood pressure medications because CBD can also lower blood pressure.
Is CBD Cream Safe?
Because CBD creams aren’t regulated by the Food and Drug Administration (FDA) as topical drug products, it’s difficult to determine their safety and efficacy as a product category. However, the American Academy of Dermatology (AAD) reports that topical CBD products may be effective in treating conditions including acne, psoriasis and eczema with few or no side effects. Ultimately, safety and efficacy depend on the specific CBD cream product and its formulation.