Why no mention of this study using the A Meta-Analysis and Meta-Regression methodology found good results for CBD pain mangment.
"2019 Effects of Cannabinoid Administration for Pain: A Meta-Analysis and Meta-Regression"
"When considering reductions in self-reported pain, we observed that cannabinoid administration was associated with a ‘medium-to-large’ (Cohen, 1988) pooled effect size across included studies. Importantly, cannabinoid administration was associated with statistically significant greater pain reduction than placebo administration, which yielded a ‘small-to-medium’ (Cohen, 1988) pooled effect size. Indeed, placebo administration has been shown to enhance expectations about pain reduction"
"When considering cannabis’s effect on pain, our primary meta-analysis outcomes suggest that cannabinoids may represent a viable option regarding pain management and treatment- outperforming corresponding placebo conditions across included studies."
This is extremely good evidence for pain management analysis including placebo testing.
Also most of the benefits seem to show themselves in the form of Full Spectrum Oil's and Products that include the whole plant extract rather than CBD isolates
Personally, i think a pattern of evidence for the limitations of current broad "general study" must affect All parties with little side effects are becoming clearer. We probably don't have the detailed information for specific definition relative to individual reactions, especially given how many testing regimes & biomarkers are still being defined, refined & discovered. But the pattern that we all react specifically & individually to All Medical conditions & treatments is undeniable. An approach to medication that can better account for this & give standards for individual customisation that is more informed than the current trial & error would be redefining for the industry, life-saving, & life changing for the patients involved. If we could find relative testable signs & causalities for issues, side effects, we could drastically increase treatment effectiveness & efficiency.
That poor one transplant patient who felt no changes. I imagine that using other pain relief was limited – at least for a bit. Ouch! There's a THC medication here in Canada that's used often, Nabilone. I wish there was more research and avaliable regulated pharmaceuticals that use CBD and THC
I think it's great that you highlight that there is no scientific evidence backing CBD (yet). Hope for chronic pain and illness is great but not when it means lying to patients/consumers to possibly only produce a placebo effect while gladly taking their money.
I’m curious, why are there so many studies that do not have a control group? This, along with tiny sample sizes raises the question: are these studies worth doing in the first place? I honestly don’t know, but my guess is that ethics comes into play when it comes to studies without control groups.
Unfortunately, a big part of the reason we see so few studies on the benefits (or lack of) from CBD and/or THC is due to it being a Schedule I substance (though CBD made from Hemp was recently excluded from the Controlled Substances Act). For those that don't know, a Schedule I drug is considered to have both a high risk of abuse and no medicinal value. The problem this creates is that not only is it nearly impossible to get funding for research in this area, in many cases it's actually illegal. Let's hope in the near future congress either removes marijuana/THC/CBD from the controlled substances act, or at least reclassifies it into a different schedule so we can get some serious research going.
I'm probably going to stop spending money on CBD after hearing this. I was kind of on the fence, and the effect was minimal. I think I would be better off saving the money and spending it on more massages or legal cannabis edibles when they become available, to deal with pain and anxiety.
I use CDB oil and I use a small dose, It doesn't stop all the pain but it takes most of the edge off to continue with my normal activities. I believe if I try more to stops all pain then there there is something wrong because most of my knee cartilage is mostly gone. Pain is your red line to prevent serious injuries. Common sense and science are never perfect but should be used together as partners to be the answer.
I found CBD excellent for inflammation reduction if taken at a high dose. It works even better than ibuprofen. However, as noted, it is expensive. I have many illnesses, take many medications, and wonder about CBD's possible effects on the liver. It is a shame that more studies have not been done. I don't take ibuprofen regularly because of liver, kidney, and stomach issues. For now, I wait for the trials.
My dad got addicted to pain medication after a back injury and a traumatic back surgery. It was a horrible time in all of our family. He started taking CBD tincture, which was recommended to him by a friend who was a practicing doctor, and after six months my dad was completely off of pain medication. A couple months after that he stopped taking the CBD tincture and it was truly like a miracle. I got my Dad back. I will forever be in support of CBD as a medical aid because I’ve seen how life changing it can be.
Just wanted to mention : I have a brother with a bad mental condition which trigerred multiple epileptic seizures per day. After starting on a hemp oil treatment, his seizures have decreased by 100x. This has given his brain a respite and has improved his quality of life
I would love for there to be more studies on CBD and pain management. I have a connective tissue disorder that results in a lot of random pain. My doctor recommended I try one specific brand of CBD that has good testing standards, from the point of view of "it could help, and probably won't hurt." More or less the same way she suggested I take a D vitamin; nothing specific, but give it a try. I can't tell if the CBD helps or not, because I don't know what a good recommended dosage or schedule should be. Mostly, it just tastes really awful. XD
I'm half way through this video and all I've learned is that you guys make videos without actual data. What is the fucking point of this video, if every study you're reviewing is less than 100 people?
Amanda and Liz both got scripts for CBD/THC sublingual spray to counter pain from chemo-induced peripheral neuropathy and chemo.
That stuff actually gave me back my big sister. She went from a mean, uncaring bitchy cunt to being a very loving, caring, empathetic person who is an amazing mama to Franky & Liz and the bestest big sister ever!
CBD/THC sublingual spray helped Elizabeth with her chemo pain.
For some it is a miracle drug like Benadryl or IV D50! ~Stevii on dad's account
no studies cuz there was no profit in just running tests with cbd on a grand scale??? only tested on an fda approved pharma med based on cbd??? very very suspicous
Hey can you do a video on all the different types of Water that people claim have health benefits like high PH water and things like that that? Or the black water?
I would like to know your thoughts on Delta 8 THC products. Claims are it gives a "good high" like Delta 9 THC but without the psychoactive effects. Any studies on it in regards to pain, anxiety, etc?
It might have been worth spending 20 seconds explaining WHY there's no good studies on CBD in the USA. Until not long ago, it was really hard to run those trials. CBD is still regulated Schedule 1, and until 2018 was treated as harshly as Heroin, LSD, Ecstasy, and the dreaded killer drug THC. Getting permission to even study it was near impossible.
I think you could do more on this subject. Neither of your videos have talked at all about how THC and CBD interact with the endocannabinoid system. I understand that there is little research available, but your reticence to even discuss these topics with enthusiasm speaks volumes about the entrenchment of moral panic. I imagine you don't consider yourself bias, but ask yourself: would you be doing this same debunking if we were talking about some other fringe medicine?
Saw a display for CBD in the window of a vape shop recently that said something like "It's supposed to be good for this stuff!" and a whole ton of ailments. Snake oil indeed, at least until the science comes in!
What is the minimum amount of test participants to be considered an effective amount for a good trial (or, one that doesn't earn an eyeroll for ineffectiveness)?
4:57 All studies so far, sound like they are a result of placebo effects. The high variety in dosage, the wide range of effects, and in some groups roughly half of them working.
If they take a small bottle of concentrated H2O (not to be confused with H2O2), they may experience similar effects.
At 3:16 it looks like one of our sources got cut off. It should read: The American Journal of Psychiatry
Hey, while you're here, thanks for watching and have a nice day 🙂
Why no mention of this study using the A Meta-Analysis and Meta-Regression methodology found good results for CBD pain mangment.
"2019 Effects of Cannabinoid Administration for Pain: A Meta-Analysis and Meta-Regression"
"When considering reductions in self-reported pain, we observed that cannabinoid administration was associated with a ‘medium-to-large’ (Cohen, 1988) pooled effect size across included studies. Importantly, cannabinoid administration was associated with statistically significant greater pain reduction than placebo administration, which yielded a ‘small-to-medium’ (Cohen, 1988) pooled effect size. Indeed, placebo administration has been shown to enhance expectations about pain reduction"
"When considering cannabis’s effect on pain, our primary meta-analysis outcomes suggest that cannabinoids may represent a viable option regarding pain management and treatment- outperforming corresponding placebo conditions across included studies."
This is extremely good evidence for pain management analysis including placebo testing.
Also most of the benefits seem to show themselves in the form of Full Spectrum Oil's and Products that include the whole plant extract rather than CBD isolates
snake oil huh? is that why CBD was able to treat my friends alcohol withdrawal symptoms and stop his seizures. @100MG a day.
I'm helping myself with Weedborn CBD. I think this is the best medicine.
Personally, i think a pattern of evidence for the limitations of current broad "general study" must affect All parties with little side effects are becoming clearer.
We probably don't have the detailed information for specific definition relative to individual reactions, especially given how many testing regimes & biomarkers are still being defined, refined & discovered.
But the pattern that we all react specifically & individually to All Medical conditions & treatments is undeniable. An approach to medication that can better account for this & give standards for individual customisation that is more informed than the current trial & error would be redefining for the industry, life-saving, & life changing for the patients involved.
If we could find relative testable signs & causalities for issues, side effects, we could drastically increase treatment effectiveness & efficiency.
I would like for you guys to add articles references in the description. It would help greatly. Thank you
That poor one transplant patient who felt no changes. I imagine that using other pain relief was limited – at least for a bit. Ouch! There's a THC medication here in Canada that's used often, Nabilone. I wish there was more research and avaliable regulated pharmaceuticals that use CBD and THC
Better than your previous attempts at tackling this topic. Though your dislike for it is still quite intense.
It seems crazy that so many people are taking something and research funds are so nonexistent that we only test people 7 at a time.
I mean, if you gave me 300 mg of cbd that would be too much and I wouldn't be able to sleep well.
I think it's great that you highlight that there is no scientific evidence backing CBD (yet).
Hope for chronic pain and illness is great but not when it means lying to patients/consumers to possibly only produce a placebo effect while gladly taking their money.
well of course there haven't been a lot of studies… big pharma can't profit off of it
I’m curious, why are there so many studies that do not have a control group? This, along with tiny sample sizes raises the question: are these studies worth doing in the first place? I honestly don’t know, but my guess is that ethics comes into play when it comes to studies without control groups.
Unfortunately, a big part of the reason we see so few studies on the benefits (or lack of) from CBD and/or THC is due to it being a Schedule I substance (though CBD made from Hemp was recently excluded from the Controlled Substances Act). For those that don't know, a Schedule I drug is considered to have both a high risk of abuse and no medicinal value. The problem this creates is that not only is it nearly impossible to get funding for research in this area, in many cases it's actually illegal. Let's hope in the near future congress either removes marijuana/THC/CBD from the controlled substances act, or at least reclassifies it into a different schedule so we can get some serious research going.
I hope the CBD information continues to get passed on to the public, thank you for sharing this!
I'm probably going to stop spending money on CBD after hearing this. I was kind of on the fence, and the effect was minimal. I think I would be better off saving the money and spending it on more massages or legal cannabis edibles when they become available, to deal with pain and anxiety.
I use CDB oil and I use a small dose, It doesn't stop all the pain but it takes most of the edge off to continue with my normal activities. I believe if I try more to stops all pain then there there is something wrong because most of my knee cartilage is mostly gone. Pain is your red line to prevent serious injuries. Common sense and science are never perfect but should be used together as partners to be the answer.
So in the study where pain was lower in all groups, does that include the placebo group?
I need to smoke on it
May God bless Dr UROMI on YouTube for helping me to get rid of my herpes virus thanks again Dr uromi you can also message him on YouTube.
I found CBD excellent for inflammation reduction if taken at a high dose. It works even better than ibuprofen. However, as noted, it is expensive. I have many illnesses, take many medications, and wonder about CBD's possible effects on the liver. It is a shame that more studies have not been done. I don't take ibuprofen regularly because of liver, kidney, and stomach issues. For now, I wait for the trials.
There should be mention of effect size more so than sample size in your videos. Just because a sample is small doesn't mean the effect was small.
Can you do a video on palmitoylethanolamide for treating chronic pain?…. There's soooo many studies on it but I'm not sure how to interpret them all.
My dad got addicted to pain medication after a back injury and a traumatic back surgery. It was a horrible time in all of our family. He started taking CBD tincture, which was recommended to him by a friend who was a practicing doctor, and after six months my dad was completely off of pain medication. A couple months after that he stopped taking the CBD tincture and it was truly like a miracle. I got my Dad back. I will forever be in support of CBD as a medical aid because I’ve seen how life changing it can be.
Please do an episode on Ozone therapy!
Just wanted to mention : I have a brother with a bad mental condition which trigerred multiple epileptic seizures per day. After starting on a hemp oil treatment, his seizures have decreased by 100x. This has given his brain a respite and has improved his quality of life
I would love for there to be more studies on CBD and pain management. I have a connective tissue disorder that results in a lot of random pain. My doctor recommended I try one specific brand of CBD that has good testing standards, from the point of view of "it could help, and probably won't hurt." More or less the same way she suggested I take a D vitamin; nothing specific, but give it a try. I can't tell if the CBD helps or not, because I don't know what a good recommended dosage or schedule should be. Mostly, it just tastes really awful. XD
I'm half way through this video and all I've learned is that you guys make videos without actual data. What is the fucking point of this video, if every study you're reviewing is less than 100 people?
This is absolute bullshit clickbait.
Yes, it does. Whenever my spine is sore, my CBD gummies make my spine no longer sore.
Amanda and Liz both got scripts for CBD/THC sublingual spray to counter pain from chemo-induced peripheral neuropathy and chemo.
That stuff actually gave me back my big sister. She went from a mean, uncaring bitchy cunt to being a very loving, caring, empathetic person who is an amazing mama to Franky & Liz and the bestest big sister ever!
CBD/THC sublingual spray helped Elizabeth with her chemo pain.
For some it is a miracle drug like Benadryl or IV D50!
~Stevii on dad's account
no studies cuz there was no profit in just running tests with cbd on a grand scale??? only tested on an fda approved pharma med based on cbd??? very very suspicous
Maybe if cannabis wasn't a Schedule 1 drug we could find some real reliable studies then!
Hey can you do a video on all the different types of Water that people claim have health benefits like high PH water and things like that that? Or the black water?
I would like to know your thoughts on Delta 8 THC products. Claims are it gives a "good high" like Delta 9 THC but without the psychoactive effects. Any studies on it in regards to pain, anxiety, etc?
It might have been worth spending 20 seconds explaining WHY there's no good studies on CBD in the USA. Until not long ago, it was really hard to run those trials. CBD is still regulated Schedule 1, and until 2018 was treated as harshly as Heroin, LSD, Ecstasy, and the dreaded killer drug THC. Getting permission to even study it was near impossible.
How does one publish a paper without controls? And why are these studies using tiny sample sizes without controls?
I think you could do more on this subject. Neither of your videos have talked at all about how THC and CBD interact with the endocannabinoid system. I understand that there is little research available, but your reticence to even discuss these topics with enthusiasm speaks volumes about the entrenchment of moral panic. I imagine you don't consider yourself bias, but ask yourself: would you be doing this same debunking if we were talking about some other fringe medicine?
Blown away by the fact there isn't more research done on CBD as a replacement therapy for opioids.
answer……………………could be.
What about studies on CBD and Autism. I've heard there were studies underway to look into this but I haven't seen anything published yet.
Your episode did not state the mechanism of action for the Rx anti seizure CBD drug. That may have been informative🤷. Is it a anti inflammatory?
Saw a display for CBD in the window of a vape shop recently that said something like "It's supposed to be good for this stuff!" and a whole ton of ailments. Snake oil indeed, at least until the science comes in!
I really wish we could have more trials on this stuff, it would also be great if we had more THCa studies.
💙💙💙
I'm suprised this hasn't been studied more in countries where cannabis has been legal for awhile now with a bigger sample size
What is the minimum amount of test participants to be considered an effective amount for a good trial (or, one that doesn't earn an eyeroll for ineffectiveness)?
4:57 All studies so far, sound like they are a result of placebo effects. The high variety in dosage, the wide range of effects, and in some groups roughly half of them working.
If they take a small bottle of concentrated H2O (not to be confused with H2O2), they may experience similar effects.